Anti-depressants with Sedative Properties
Amitriptyline, clomipramine, dothiepin, doxepin, maprotiline and mianserin.
Anti-depressants with Minimal Sedative Properties
Sertraline and Fluoxetine
Tricyclics and related anti-depressants should be used for at least 2 weeks before the suppression of symptoms can be anticipated.
After these, the dose should not be altered for at least one month.
Remission usually occurs after 3 months to one year and above.
Anti-depressants should not be discontinued abruptly.
General Side Effects of Tricyclic Anti-depressants
Antimuscarinic actions namely: drowsiness, urinary retention, dry mouth, constipation, blurred vision, sweating, hypotensive effect (which may lead to dizziness and syncope).
Arrhythmias and heart block, convulsion, haematological and hepatic disorders.